Vytorin
 

Ezetimibe/simvastatin

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Ezetimibe/simvastatin
Combination of
Ezetimibe via Niemann-Pick C1-Like 1 protein
Simvastatin Statin HMG-CoA_reductase inhibitor
Identifiers
CAS number  ?
ATC code C10BA02
PubChem  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

℞ Prescription only

Routes Oral

Ezetimibe/simvastatin (pronounced /ɛˌzɛtɨmɪb ˌsɪmvəˈstætɨn/) is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (best known as Zetia in the United States) and the statin drug simvastatin (best known as Zocor in the U.S.). The combination preparation is marketed by Merck & Co./Schering-Plough Pharmaceuticals (joint venture) under the trade names Vytorin and Inegy.

Ezetimibe reduces blood cholesterol by inhibiting absorption of cholesterol by the small intestine by acting at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.

Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that is necessary for the body to make cholesterol.

Summary Provided Under GNU Free Documentation License




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The FDA is investigating a report of a possible association between the use of Vytorin and a potentially increased incidence of cancer. Vytorin is a combination of Zocor and Zetia and is generally prescribed to reduce LDL-cholesterol ...

Vytorin (Ezetimibe & Simvastatin) - updated on RxList
Vytorin (Ezetimibe & Simvastatin) drug description - FDA approved labeling for prescription drugs and medications at RxList.

FDA investigates possible Vytorin-cancer link
US drug regulators are investigating whether the cholesterol-lowering drug Vytorin might be linked to cancer. The US Food and Drug Administration informed health-care professionals that the agency was investigating a report from the ...

Philadelphia Inquirer, The - Lawsuits target Vytorin's makers
Merck & Co. and Schering Plough Corp., makers of the cholesterol-lowering combination drug Vytorin, are getting hit with a wave of lawsuits asserting the companies knew its product didn't work and delayed telling the public about it. ...









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