Ezetimibe/simvastatin
|
Ezetimibe/simvastatin
|
|
| Combination of | |
| Ezetimibe | via Niemann-Pick C1-Like 1 protein |
| Simvastatin | Statin HMG-CoA_reductase inhibitor |
| Identifiers | |
| CAS number | ? |
| ATC code | C10 |
| PubChem | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | Oral |
Ezetimibe/simvastatin (pronounced /ɛˌzɛtɨmɪb ˌsɪmvəˈstætɨn/) is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (best known as Zetia in the United States) and the statin drug simvastatin (best known as Zocor in the U.S.). The combination preparation is marketed by Merck & Co./Schering-Plough Pharmaceuticals (joint venture) under the trade names Vytorin and Inegy.
Ezetimibe reduces blood cholesterol by inhibiting absorption of cholesterol by the small intestine by acting at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.
Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that is necessary for the body to make cholesterol.
Summary Provided Under GNU Free Documentation LicenseLive From The Blogosphere!
ENHANCE study of Vytorin and Zetia has drawn considerable media attention, but stopping cholesterol medications based on this study alone is not appropriate. The next step for any concerned patient with high cholesterol is to talk with ...
WHITEHOUSE STATION & KENILWORTH, NJ — Large Trial to Evaluate VYTORIN(TM) in Reducing Major Cardiovascular Events Through Intensive Lowering of LDL Cholesterol in Patients with Acute Coronary Syndromes ...
Does Vytorin increase the risk of cancer death? The question seems like it would be simple to answer, yet finding the answer requires navigating through a murky labyrinth of botched test results, apparent cover-ups, possible payoffs, ...
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The FDA is investigating a report of a possible association between the use of Vytorin and a potentially increased incidence of cancer. Vytorin is a combination of Zocor and Zetia and is generally prescribed to reduce LDL-cholesterol ...
Vytorin (Ezetimibe & Simvastatin) drug description - FDA approved labeling for prescription drugs and medications at RxList.
US drug regulators are investigating whether the cholesterol-lowering drug Vytorin might be linked to cancer. The US Food and Drug Administration informed health-care professionals that the agency was investigating a report from the ...
Merck & Co. and Schering Plough Corp., makers of the cholesterol-lowering combination drug Vytorin, are getting hit with a wave of lawsuits asserting the companies knew its product didn't work and delayed telling the public about it. ...
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