Trasylol
 

Aprotinin

  (Redirected from Trasylol)
Aprotinin
Systematic (IUPAC) name
Aprotinin
Identifiers
CAS number 9087-70-1
ATC code B02AB01
PubChem N/A
Chemical data
Formula C284H432N84O79S7 
Mol. mass 6511.51
Synonyms trasylol, bovine pancreatic trypsin inhibitor
Pharmacokinetic data
Bioavailability 100% (IV)
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

X
Legal status

RX/POM
Dependence Liability none
Routes intravenous

Aprotinin, also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death.[1]

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