Progivil
 

Modafinil

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Modafinil
Systematic (IUPAC) name
2-benzhydrylsulfinylethanamide
Identifiers
CAS number 68693-11-8
ATC code N06BA07
PubChem 4236
DrugBank APRD00534
Chemical data
Formula C15H15NO2S 
Mol. mass 273.351 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding 60%
Metabolism Hepatic, including CYP3A4 and other pathways
Half life 8–18 hours
Excretion Urine (as metabolites)
Therapeutic considerations
Pregnancy cat.

C
Legal status

Schedule IV (US), POM (UK)
Routes Oral

Modafinil, also known as Provigil (U.S. brand-name), is a stimulant drug manufactured by Cephalon, and is approved by the FDA for the treatment of narcolepsy.[1] Modafinil, like other stimulants, increases the release of monoamines, but also elevates histamine levels in certain discrete brain regions,[2] leading some researchers to consider Modafinil a "wakefulness promoting agent" rather than a classic stimulant. The drug is sometimes prescribed off-label for Attention-Deficit Hyperactivity Disorder (ADHD). In mass-media advertisements and websites, Cephalon markets the drug for improving "alertness" and reducing excessive daytime sleepiness.

Modafinil was invented in France during the late 1970s, along with the similar and very much less expensive drug adrafinil. Modafinil is the primary metabolite of adrafinil and while their activity is similar, adrafinil is slower-acting.

Summary Provided Under GNU Free Documentation License




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