Abatacept

(Redirected from Orencia)

Abatacept
Systematic (IUPAC) name
Unable to be assigned
Identifiers
CAS number	?
ATC code	L04AA24
PubChem	?
Chemical data
Formula	?
Mol. mass	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C (U.S.)
Legal status	POM (UK), ℞-only (U.S.)
Routes	Intravenous

Abatacept (marketed as Orencia) is a fusion protein composed of an immunoglobulin fused to the extracellular domain of CTLA-4, a molecule capable of binding B7. Abatacept is a selective costimulation modulator as it inhibits the costimulation of T cells. It was developed by Bristol-Myers-Squibb and is licensed in the United States for the treatment of rheumatoid arthritis in the case of inadequate response to anti-TNFα therapy.

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